Optical signal-based improvement of individual nanoparticle tracking analysis

Abstract Nanoparticle Tracking Analysis (NTA) provides a simple method to determine individual nanoparticle size. However, because size quantification is based on the slowly converging statistical law of random event, its intrinsic error large, especially in case limited event number, e.g. for weak scattering nanoparticles. Here, we introduce an NTA improvement by analyzing each NP trajectory while taking into account other trajectories with weighting coefficient. This coefficient directly derived from optical signature particle measured quantitative phase microscopy. The simulations and experimental results demonstrate accuracy, not only mono-disperse but also poly-disperse solutions.